脓毒症(sepsis)是指由感染因素导致的全身性炎症反应综合征(systemic inflammatory response syndrome,SIRS),是临床上严重感染患者常见的致命性并发症,也是感染患者死亡的主要原因。目前,全球脓毒症发病率为(50~95)/100 000,并以每年9%的速度上升,预计全球每年有1 900万病例[1-2]。脓毒症的病死率长期居高不下,其中重症脓毒症病死率为25%~ Sepsis is a systemic inflammatory response syndrome (SIRS) caused by infectious agents. It is a common fatal complication in patients with clinically serious infections and the main cause of death in infected patients. Currently, the global incidence of sepsis is (50-95) / 100 000 and is rising at a rate of 9% per annum. It is estimated that there are 19 million cases worldwide each year [1-2]. The mortality rate of sepsis long-term high, of which severe sepsis mortality rate of 25% ~