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本文进一步报告铜蓝蛋白(Ceruloplasmin简称Cp)对体外培养的2BS细胞的增殖有促进作用。在Cp(600微克/毫升)作用下,参入2BS细胞的[~3H]—胸腺嘧啶核苷增加1.05倍,并且分泌到培养液的胶原蛋白的L[~3H]—脯氨酸的CPM值增加1.03倍。这些实验结果提示在矽肺中Cp的增加可能会促进细胞的过份增殖和胶原蛋白的增多。
This article further reports ceruloplasmin (Ceruloplasmin abbreviation Cp) on the proliferation of 2BS cells in vitro promote the role. Under the action of Cp (600 μg / ml), [~ 3H] -thymidine incorporation in 2BS cells increased 1.05-fold and the CPM value of L [~ 3H] -proline secreted into the culture medium increased 1.03 times. These experimental results suggest that an increase in Cp in silicosis may promote excessive proliferation of cells and an increase in collagen.