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目的 观察小剂量重组组织型纤溶酶原激活剂 (rt PA)加速溶栓疗法治疗急性心肌梗死 (AMI)的疗效。方法 将急诊入院的急性心肌梗死患者 5 8例用小剂量rt PA治疗 :入院后即给予rt PA 8mg静脉推注后将 4 2mgrt PA用推注泵在 6 0min内推完。溶栓后续用肝素静滴维持 3d以上。 结果 90min再通率为 72 4 % (42 / 5 8) ,出血等并发症发生率 8 3% (4/ 4 8)。结论 小剂量重组组织型纤溶酶原激活剂 (rt PA)加速溶栓疗法治疗急性心肌梗死效果显著 ,且不良反应少。
Objective To observe the effect of low dose recombinant tissue plasminogen activator (rt PA) on accelerating thrombolytic therapy in patients with acute myocardial infarction (AMI). Methods Fifty-eight acute myocardial infarction patients admitted to the hospital with low-dose rt PA were given intravenous injection of rt PA 8 mg after admission, and 4 2 mgrt PA was pumped by bolus injection within 60 min. Thrombolysis followed by intravenous infusion of heparin to maintain more than 3d. Results The 90% recanalization rate was 72.4% (42/58). The complication rate of bleeding was 83% (4/48). Conclusion The effect of low-dose recombinant tissue-type plasminogen activator (rt PA) in accelerating thrombolytic therapy in patients with acute myocardial infarction is remarkable with less adverse reactions.