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目的：评价卵巢癌P-糖蛋白、P53、P185表达对近期化疗效果的影响及相互关系。方法：免疫组织化学ABC法检测49例卵巢癌P-糖蛋白、GST－π、P53、P185表达。结果：1.卵巢癌P-糖蛋白、GST－π、P53、P185表达阳性者的近期化疗有效率分别为14．3％。27．3％、41、67％、24、63％，而表达阴性者的近期化疗有效率分别为53．6％（P0．05）、75．0％（P<0．005）。2．P-糖蛋白、P185的表达存在相关性（P＜0．05）。结论：卵巢癌P-糖蛋白、GST－π、P185的表达明显影响其近期化疗效果。P-糖蛋白、P185表达的相关性值得进一步研究。
OBJECTIVE: To evaluate the effect of P-glycoprotein, P53 and P185 expression in ovarian cancer on the effect of recent chemotherapy and their correlation. Methods: Immunohistochemical ABC method was used to detect the expression of P-glycoprotein, GST-π, P53, P185 in 49 cases of ovarian cancer. The results showed that: 1. The effective rates of recent chemotherapy for P-glycoprotein, GST-π, P53 and P185 in ovarian cancer were 14.3%. 27.3%, 41.67%, 24.63% respectively. The effective rates of chemotherapy in the negative patients were 53.6% (P <0.005) and 56.3% (P <0.005) respectively, 48.2% (P> 0.05), 75.0% (P <0.005). 2. P-glycoprotein, P185 expression was correlated (P <0.05). Conclusion: The expression of P-glycoprotein, GST-π and P185 in ovarian cancer significantly affects the effect of recent chemotherapy. The relevance of P-glycoprotein, P185 expression warrants further investigation.