论文部分内容阅读
渗透泵控释片是制药行业的新剂型,因恒定的释药速率对疗效的明显提升而受到青睐。释药孔决定控释片的溶出度,而释药孔的成型方法中激光打孔优势明显。在研制的专用激光打孔设备上进行了释药孔的打孔实验研究,确定了离焦量、激光电流、激光脉宽等参数所起的不同作用。发现离焦量主要影响孔径:激光电流(激光功率)主要影响碳化层;激光脉宽主要影响孔深等。这些现象和规律对提高渗透泵控释片激光打孔的效率和质量具有指导或参考作用,对发展渗透泵控释片产业非常有意义。
Osmotic pump controlled release tablets are new dosage forms in the pharmaceutical industry, and are favored by the constant release rate for the significant improvement in efficacy. Release hole determines the release of controlled release tablets, while the injection hole forming method laser drilling obvious advantages. In the developed special laser drilling equipment on the hole of the drug release hole experiments to determine the amount of defocus, laser current, laser pulse width and other parameters played a different role. It is found that the defocusing quantity mainly affects the aperture: the laser current (laser power) mainly affects the carbonization layer; and the laser pulse width mainly affects the hole depth and the like. These phenomena and rules to improve the efficiency and quality of osmotic pump controlled release tablets laser drilling guide or reference, the development of osmotic pump controlled release tablets industry is very meaningful.