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24只幼龄菲律宾猕猴(Macaca phili-ppinensis philippinensis),体重0.8～2.1公斤,隔离检查21天后,切除脾脏,以增强对疟疾感染的易感性。脾切除后4～8周,以当地恶性疟患者的新鲜血液进行腹腔接种,30天后如未发生明显感染者给予再次接种。为了抑制免疫反应,在接种前后还给猴肌注了硫唑嘌呤,开始剂量为50毫克/公斤,第2天和第3天的剂量为2.5毫克/公斤,在第1次注
Twenty-four young macaques (Macaca phili-ppinensis philippinensis), weighing 0.8-2.1 kg, were sacrificed 21 days after isolation and resection of the spleen to enhance their susceptibility to malaria infection. 4 to 8 weeks after splenectomy, intraperitoneal inoculation with fresh blood of local falciparum malaria patients, and re-inoculation after 30 days if no significant infection occurs. In order to suppress the immune response, azathioprine was given to the monkey muscle before and after inoculation at a starting dose of 50 mg / kg and on the second and third days at a dose of 2.5 mg / kg. In the first injection