论文部分内容阅读
肖小球系膜细胞（ＭＣ）及其胞外基质（ＥＣＭ）、细胞因子在肾小球疾病的发生发展中有重要作用。ＭＣ研究需关注种属差异，ＭＣ培养有助于研究糖尿病、脂质性肾小球肾炎的病理过程。ＥＣＭ主要由ＭＣ等分泌。ＥＣＭ随肾内细胞增殖而增殖，多种类型肾炎发展与此有关。细胞因子ＰＤＧＦ、ＴＧＦ、ＩＬ－１、ＩＬ－６、ＴＮＦｘ及活性物质如内皮素、Ａｎｇ、植物凝集素、ＴＳＰ等对ＭＣ有重要影响，这在病理情况下更具意义。
Schwann cell mesangial cells (MC) and its extracellular matrix (ECM), cytokines play an important role in the development of glomerular diseases. MC studies need to pay attention to species differences, MC culture helps to study the pathology of diabetes, lipid glomerulonephritis. ECM is mainly secreted by MC and others. ECM proliferation with proliferation of renal cells and proliferation, the development of many types of nephritis with this. The cytokines PDGF, TGF, IL-1, IL-6, TNFx and active substances such as endothelin, Ang, lectin, TSP and other MC have a significant impact, which is more meaningful in the pathological conditions.