1 PC概述PC属于维生素K依赖性双链糖蛋白,由单链和双链分子混合构成的,其中双链由氨基酸的轻链与氨基酸的重链通过Cys141和Cys277间二硫键连接构成,是血浆中PC的主要存在形式~([1])。成熟的PC可以在结构上分成3个区域:(1)N端的γ-羧基谷氨酸区域,这个区域是PC结合钙离子所必需的;(2)2个表皮生长因子同源区,是PC被激活的重要区域;(3)C端的丝氨酸蛋白酶区域,这是PC的活性区域。PC大部分 1 PC Overview PC is a vitamin K-dependent double-stranded glycoprotein consisting of a mixture of single- and double-stranded molecules in which the double-stranded chain consists of the heavy chain of an amino acid and the heavy chain of an amino acid linked via a disulfide bond between Cysl41 and Cys277 and is The main form of PC in plasma ~ ([1]). The mature PC can be structurally divided into three regions: (1) the N-terminal γ-carboxyglutamate region, which is required for the PC to bind to calcium ions; and (2) two epidermal growth factor homologous regions, which are PC An important region to be activated; and (3) a C-terminal serine protease region, which is the active region of the PC. Most PC