论文部分内容阅读
文章简介出血性脑卒中和脑出血是由脑血管破裂引起的。快速修复这种破裂是最有希望的治疗方法。由于缺乏高分辨率的体内实时研究,脑血管修复过程中的动态细胞事件仍然未知。在本研究中,研究人员在斑马鱼中开发出脑血管破裂系统,通过使用多光子激光产生具有两个内皮末端的损伤。体内延时成像显示,巨噬细胞到达损伤处并延长丝状伪足以物理方式粘附于内皮末端。这种巨噬细胞产生机械牵引
Introduction to the article Hemorrhagic stroke and cerebral hemorrhage is caused by ruptured cerebrovascular. Quick repair of this rupture is the most promising treatment. Due to the lack of high-resolution in vivo real-time studies, the dynamic cellular events during cerebrovascular repair remain unknown. In this study, researchers developed a cerebrovascular disruption system in zebrafish that produces damage with two endothelial terminals by using a multiphoton laser. In vivo delayed imaging shows that macrophages reach the lesion and prolong the filopodia to physically adhere to the end of the endothelium. This macrophage produces mechanical traction