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对１００例动脉粥样硬化（ＡＳ）患者（其中冠心病６０例，脑卒中４０例）测定血清脂蛋白（ａ）（Ｌｐ（ａ）），载脂蛋白ＡＩ（ａｐｏＡＩ），载脂蛋白Ｂ（ａｐｏＢ）及其他血脂，并与对照组１００例健康体检者作比较。结果表明：ＡＳ组Ｌｐ（ａ）水平较对照组有显著差异（Ｐ＜０．０１）；ＡＳ组高Ｌｐ（ａ）检测率较对照组亦有显著差异（Ｐ＜０．０１）；ＡＳ组Ｌｐ（ａ）升高与ａｐｏＡＩ呈负相关；与胆固醇（Ｃｈ）、甘油三酯（ＴＧ）、ａｐｏＢ均无相关性。提示Ｌｐ（ａ）是诊断ＡＳ的敏感指标，亦是ＡＳ的独立危险因素，人群中检测Ｌｐ（ａ）对预测心脑血管疾病有重要意义。
Serum lipoprotein (a) (Lp (a)), apolipoprotein AI (apoAI), apolipoprotein B (apoAI) and serum lipids were measured in 100 patients with atherosclerosis (AS), including 60 cases of coronary heart disease and 40 cases of stroke. apoB) and other blood lipids, and compared with 100 healthy people in the control group. The results showed that the level of Lp (a) in AS group was significantly lower than that in control group (P <0.01), and the detection rate of high Lp (a) in AS group was also significantly different from that in control group (P <0.01) Lp (a) increased negative correlation with apoAI; and cholesterol (Ch), triglyceride (TG), apoB no correlation. It is suggested that Lp (a) is a sensitive index for the diagnosis of AS and an independent risk factor for AS. The detection of Lp (a) in the population is of great significance for the prediction of cardiovascular and cerebrovascular diseases.