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为观察治痫灵对癫痫的影响,采用红藻氨酸造模,随机将30 只实验性癫痫大鼠分为模型组、西药组、中药组。按Schultz-Krohn 的标准观察行为表现,并以湿狗样甩动作为主要指标,另以平均频率与波幅作为脑电指标。结果显示治痫灵中药组与模型组、丙戊酸钠西药组相比,癫痫发作潜伏时延长,湿狗样甩动的次数减少,脑电频率变化不大、波幅增高不显著,这些差异均有统计学意义,提示治痫灵有显著的抗痫作用,其机理可能是抑制钙离子内流,改善脑循环。
To observe the effect of ZhiXianLing on epilepsy, kainic acid was used to model and 30 experimental epilepsy rats were randomly divided into model group, western medicine group and Chinese medicine group. The behavioral performance was observed according to Schultz-Krohn’s criteria, and wet dog-like fling was used as the main indicator, and the mean frequency and amplitude were used as EEG indicators. The results showed that compared with the model group and the sodium valproate group, the seizures of Chinese traditional medicine group had longer seizure latency, fewer wet dog-like shaking times, little change in brain power frequency, and no significant increase in amplitude. These differences were both significant. Statistically significant, suggesting that treatment of epilepsy has significant anti-epilepsy, the mechanism may be to inhibit calcium influx and improve cerebral circulation.