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研究背景:在过去10年间,Glasgow地区新生儿戒断综合征(NAS)的发病率增加了10倍。女王皇家妇产科医院特殊监护婴儿病房(SCBU)收治的患儿中,有17%即为该病。目的:对比阿片类替代物(硫酸吗啡)疗法和现行的标准疗法(苯巴比妥)对于NAS的疗效。初级研究终点是药物治疗的疗程,次级终点是需要进行附
Background: The incidence of neonatal withdrawal syndrome (NAS) in the Glasgow region has increased ten-fold in the past decade. 17% of children admitted to the Queen’s Maternity Hospital Special Nursing Ward (SCBU) are affected. OBJECTIVE: To compare the efficacy of opioid replacement (morphine sulphate) therapy with current standard therapy (phenobarbital) for NAS. The primary endpoint is medications, and secondary endpoints are required