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目的 评价肿瘤化疗敏感性检测对肿瘤预见性化疗的作用。方法 用ＭＴＴ法测定膀胱癌对４种化疗药物的敏感性，并对据此进行的化疗效果进行随访。共６２ 例行保留膀胱手术的病人，分为药敏组３２例，根据药敏结果选最敏感的一种药物膀胱灌注；对照组３０ 例根据经验用丝裂霉素膀胱灌注。结果 膀胱癌对化疗药物的敏感性存在个体差异，药敏组的单位时间复发率显著低于对照组（ Ｐ＜ ０－０５） 。结论 ＭＴＴ法能客观地指导临床医生选择化疗药物，提高癌的化疗疗效。
Objective To evaluate the effect of tumor chemosensitivity testing on tumor-predictive chemotherapy. Methods The sensitivity of bladder cancer to four chemotherapeutic drugs was measured by MTT assay, and the effect of chemotherapy was followed up. A total of 62 patients undergoing bladder surgery were divided into drug sensitivity group (32 cases). According to the drug sensitivity test, the most sensitive drug was selected as bladder instillation. In the control group, 30 cases were treated with mitomycin bladder in accordance with experience. Results There were individual differences in the sensitivity of bladder cancer to chemotherapeutic drugs. The recurrence rate per unit time in the drug sensitivity group was significantly lower than that in the control group (P < 0-05). Conclusion The MTT method can objectively guide clinicians to choose chemotherapeutic drugs and improve the efficacy of cancer chemotherapy.