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目的探讨拉贝洛尔联合硫酸镁治疗重度妊娠高血压综合征(PIH)的临床疗效。方法 76例重度PIH患者作为研究对象,按照随机对照原则将患者分为对照组和观察组,每组38例。对照组患者给予硫酸镁治疗,观察组患者在对照组基础上应用拉贝洛尔治疗,观察两组疗效及母婴结局。结果观察组患者总有效率为92.1%,明显高于对照组患者的73.7%,差异有统计学意义(P<0.05)。观察组剖宫产率、产后出血率、早产率、胎儿窘迫发生率以及新生儿死亡率均低于对照组,差异有统计学意义(P<0.05)。结论拉贝洛尔联合硫酸镁治疗重度PIH的疗效可靠,能够改善母婴结局,可在临床推广应用。
Objective To investigate the clinical efficacy of labetalol combined with magnesium sulfate in the treatment of severe pregnancy-induced hypertension (PIH). Methods Seventy-six patients with severe PIH were divided into control group and observation group according to the principle of randomized control. Each group included 38 patients. The patients in the control group were treated with magnesium sulfate. The patients in the observation group were treated with labetalol on the basis of the control group. The curative effect and maternal and infant outcome were observed in both groups. Results The total effective rate of the observation group was 92.1%, which was significantly higher than that of the control group (73.7%), the difference was statistically significant (P <0.05). Cesarean section rate, postpartum hemorrhage rate, preterm birth rate, fetal distress rate and neonatal mortality rate in the observation group were lower than those in the control group, with statistical significance (P <0.05). Conclusion The effect of labetalol combined with magnesium sulfate in the treatment of severe PIH is reliable and can improve the outcome of maternal and infant, which can be popularized and applied clinically.