采用免疫组化方法，结合临床病理，检测了１１例嗅神经母细胞瘤的神经特异性烯醇化酶（ＮＳＥ）、神经纤维蛋白（ＮＦ）、Ｓ－１００蛋白（Ｓ－１００）、神经胶质纤维酸性蛋白（ＧＦＡＰ）、角蛋白（Ｋｅｒａｔｉｎ）和白细胞共同抗原（ＬＣＡ）。结果显示：瘤细胞以片状、梁索状排列为特征，细胞间可见胞浆突起形成的嗜酸性纤维；ＮＳＥ，ＮＦ，Ｓ一１００阳性检出率分别为１００％、４５．５％、２７．３％，其它组化结果阴性。作者认为，ＮＳＥ对该病诊断有特异性价值，其它组化检测有助于诊断与鉴别诊断。 Immunohistochemistry and clinicopathology were used to detect the expression of neuroendocrine enolase (NSE), neurofibrin (NF), S-100 protein (S-100), glial Fibrillary acidic protein (GFAP), keratin and leukocyte common antigen (LCA). The results showed that the tumor cells were characterized by lamellar and cord-like arrangement with eosinophilic fibers formed by cytoplasm protrusion. The positive detection rates of NSE, NF and S-100 were 100%, 45.5%, 27 .3%, other histochemical results negative. The authors believe that NSE has a specific value for the diagnosis of the disease, other histological tests contribute to the diagnosis and differential diagnosis.