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目的探讨乙型肝炎病毒(HBV)感染与IgA肾病发病的关系。方法32例肾活检冰冻切片组织HBsAg和HBcAg蛋白和42例HBsAg阳性的肾活检石蜡切片组织及其部分血清HBV-DNA的检测。结果HBsAg和HBcAg在IgA肾病肾活检组织的总阳性率为59.1%,在非IgA肾病中的总阳性率为63.6%,二者差异无统计学意义。42例肾活检组织中,仅发现有5例(11.9%)在肾活检组织中有HBV-DNA的存在。且5例均为大三阳患者,其病理诊断为系膜增生性肾小球肾炎2例,轻微肾小球病变1例,基底膜病变1例,IgA肾病仅1例。血清HBsAg阳性的患者,同时进行了42例肾活检组织的血清HBV-DNA检测,其中大三阳患者为12例,其血清HBV-DNA均为阳性,而这12例血清阳性的肾活检组织中仅有5例HBV-DNA为阳性,其余30例血清及肾活检组织中HBV-DNA为阴性。结论HBsAg和HBcAg蛋白在IgA肾病肾活检组织和非IgA肾病肾活检组织表达差异无统计学意义,表明HBV感染与IgA肾病并无直接关系。
Objective To investigate the relationship between hepatitis B virus (HBV) infection and IgA nephropathy. Methods 32 cases of renal biopsy frozen sections of HBsAg and HBcAg protein and 42 cases of HBsAg positive renal biopsy paraffin sections and serum HBV-DNA detection. Results The total positive rate of HBsAg and HBcAg in renal biopsy of IgA nephropathy was 59.1%, while the positive rate of non-IgA nephropathy was 63.6%. There was no significant difference between the two. Of 42 renal biopsies, only 5 (11.9%) had HBV-DNA in renal biopsies. And 5 cases were large positive patients, the pathological diagnosis of mesangial proliferative glomerulonephritis in 2 cases, 1 case of mild glomerular lesions, 1 case of basement membrane disease, IgA nephropathy in only 1 case. Serum HBsAg-positive patients, while 42 cases of renal biopsy tissue serum HBV-DNA test, of which 12 cases of positive patients with positive serum HBV-DNA are positive, and these 12 cases of serum-positive renal biopsy tissue Only 5 cases of HBV-DNA positive, the remaining 30 cases of serum and kidney biopsy HBV-DNA was negative. Conclusion The expression of HBsAg and HBcAg protein in renal biopsy tissues of IgA nephropathy and non-IgA nephropathy tissues showed no significant difference, indicating that HBV infection is not directly related to IgA nephropathy.