论文部分内容阅读
成人呼吸窘迫综合征(ARDS)是重危病人常见的呼吸衰竭型式之一,病死率相当高。著者在1次ARDS病人气管、支气管分泌物中观察到单纯疱疹性病毒(HSV)后,对一系列的ARDS病人进行了系统性的HSV研究。诊断ARDS的标准,必须具备:1.临床上有呼吸衰竭的表现,实验室证实有动脉低血氧且严重到必须用机械辅助呼吸;2.以往有肺部疾病或直接肺部损伤的严重病人中;3.伴有非心源性肺水肿,X线可见双侧肺浸润。另一组同时住院无ARDS,但有呼吸衰竭需要插管和人工呼吸的病人作为前瞻性的对照。气管、支气管分泌物用消毒的气管导管吸取,采用严格的无菌技术,每周检查支气管上皮细胞内特征性的HSV包涵体,如果找到包涵体再用直接免疫荧光检查,并培养于人胎成纤维细胞中。
Adult respiratory distress syndrome (ARDS) is one of the most common forms of respiratory failure in critically ill patients and has a high case fatality rate. The authors conducted a systematic HSV study of a series of ARDS patients after herpes simplex virus (HSV) was observed in tracheal and bronchial secretions from 1 ARDS patients. The criteria for the diagnosis of ARDS must include: 1. clinical manifestations of respiratory failure, laboratory confirmed arterial hypoxemia and severe mechanical ventilation must be assisted; 2. In the past, patients with severe lung disease or direct lung injury ; 3. accompanied by non-cardiogenic pulmonary edema, bilateral bilateral bilateral lung infiltration. Another group of patients who were hospitalized without ARDS but who had respiratory failure requiring intubation and artificial respiration served as prospective controls. Trachea, bronchial secretions with sterile tracheal tube draw, the use of strict aseptic technique, a weekly examination of bronchial epithelial cells characteristic HSV inclusion bodies, and then find the inclusion body and then by direct immunofluorescence and cultured in human fetal Fibroblasts.