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克咳敏(Dioxopromethazioe,双氧异丙嗪)首先由民主德国发现并作为镇咳、脱敏药用于临床。国内丹东制药厂合成生产。本药镇咳疗效高于克喘素,与磷酸可待因相似,而无后者滞痰、成瘾及抑制呼吸等缺点,但平喘作用较弱,不能单独用于平喘治疗。为增强药物的平喘疗效,我们根据β_2-受体兴奋剂与茶碱合用疗效协同的作用机理,在克咳敏中加入克喘
Dikephedrone (Dioxopromethazio) was first discovered by Democrat Germany and used as an antitussive and desensitization drug in clinical practice. Dandong domestic pharmaceutical factory synthesis production. The antitussive efficacy of the drug is higher than that of kystokinase, which is similar to codeine phosphate without the disadvantages of the latter including sputum phlegm, addiction and respiration. However, the antitussive effect is weak and can not be used alone for the treatment of asthma. To enhance the efficacy of antiasthmatic drugs, we based on the β_2-receptor agonists and theophylline combined with the mechanism of the mechanism of action, Keke Min added Kechuan