恶性肿瘤的转移是患者预后不良的重要原因。如何发现和判断转移是人们研究的热点,特别是肿瘤隐匿性转移的早发现、早诊断、早治疗也越来越受到重视。近年来免疫组织化学和分子生物技术的应用在隐匿性转移的研究中逐渐显示出优势,尤其在DNA和RNA水平上的研究可能提供更多的信息。文章就近年来肿瘤转移抑制基因KAI1在淋巴结隐匿转移中的研究进展进行综述。 Malignant tumor metastasis is an important reason for the poor prognosis of patients. How to find and judge the metastasis is a hot research topic, especially the early detection, early diagnosis and early treatment of occult tumor metastasis. In recent years, the application of immunohistochemistry and molecular biotechnology has gradually shown the advantages in the study of occult metastasis, especially the research on DNA and RNA level may provide more information. This review summarizes the recent progress in the study of tumor metastasis suppressor gene KAI1 in occult metastasis of lymph nodes.