pl6蛋白最初是从各种肿瘤病毒转化的细胞中鉴定出的一种CDK4相关蛋白l’］。p］6基因被发现后，已有一些文献『‘－’］对其在肺癌中出现的基因缺失和突变进行了报道，但关于原发性肺癌中p16基因的突变和表达与患者的病理及临床资料相结合的研究目前还少见报道。本文采用?.. The pl6 protein was originally a CDK4-associated protein l' identified from various tumor virus-transformed cells. After the discovery of the p]6 gene, there have been reports of gene deletions and mutations in lung cancer that have been reported in the literature, but the p16 gene mutation and expression in patients with primary lung cancer is associated with the pathology of the patient. The combination of clinical data is rarely reported. This article uses ?..