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目的探讨胃癌组织环氧合酶-2(COX-2)异常表达与螺旋CT的关系。方法用免疫组化(SP)方法检测胃癌手术切除67例标本中上述基因表达。结果胃癌COX-2过表达率为70.1%(47/67),且过表达与肿瘤大小、大体类型、组织学类型、淋巴结转移(LN)及临床病理分期密切相关(P<0.05)。结论胃癌COX-2异常表达与螺旋CT征象密切相关。
Objective To investigate the relationship between cyclooxygenase-2 (COX-2) abnormal expression and spiral CT in gastric cancer. Methods Immunohistochemical (SP) method was used to detect the expression of the above 67 genes in gastric cancer. Results The overexpression rate of COX-2 in gastric cancer was 70.1% (47/67). The overexpression of COX-2 was closely related to tumor size, gross type, histological type, lymph node metastasis (LN) and clinicopathological stage (P <0.05). Conclusion Abnormal expression of COX-2 in gastric cancer is closely related to spiral CT signs.