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目的:比较氧化低密度脂蛋白(ｏｘ－ＬＤＬ)对兔离体颈动脉和基底动脉的内皮依赖的舒张的影响。方法:以血管条等长张力法测定ｏｘ－ＬＤＬ、Ｌ－精氧酸(Ｌ－ａｒｇｉｎｉｎｅ,Ｌ－Ａｒｇ)等对兔动脉内皮依赖的舒张功能的影响。结果:较低浓度的ｏｘ－ＬＤＬ(５０μＧ·ｍｌ－１)明显抑制颈动脉经乙酰胆碱介导内皮依赖的舒张,而不抑制非内皮依赖的舒张。Ｌ－Ａｒｇ可部分逆转ｏｘ－ＬＤＬ密度脂蛋白引起的颈动脉内皮依赖的舒张功能损害。结论:ｏｘ－ＬＤＬ可抑制兔颈动脉内皮依赖的舒张而不影响基底动脉内皮依赖的舒张,补充Ｌ－Ａｒｇ可改善受损的内皮依赖的舒张功能。
AIM: To compare the effects of ox-LDL on endothelium-dependent relaxation in isolated carotid artery and basilar artery in rabbits. Methods: The effects of ox-LDL and L-arginine on the endothelium-dependent diastolic function of rabbit artery were determined by isometric tension method. Results: Lower concentrations of ox-LDL (50μG · ml-1) significantly inhibited carotid artery mediated acetylcholine-mediated endothelium-dependent relaxation without inhibiting endothelium-independent relaxation. L-Arg partially reversed ox-LDL-induced loss of carotid endothelium-dependent diastolic function. Conclusion: ox-LDL can inhibit endothelium-dependent relaxation of rabbit carotid artery without affecting the endothelium-dependent relaxation of basilar artery. Supplementation of L-Arg can improve the impaired endothelium-dependent diastolic function.