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目的为了进一步探讨支气管哮喘的发病机理。方法采用双抗体夹心酶联免疫吸附（ELISA）法，检测了30例支气管哮喘发作期、20例缓解期患者以及20例健康对照者血浆中可溶性细胞间粘附分子（sICA－1）水平和IgE水平。结果急性发作期、缓解期支气管哮喘患者的sICAM－1和IgE分别为282.7±79.5（ng/L）、205.6±64.7（ng/L）和359.1±107.8、236.2±64.5（IU／ml）较健康对照者（163.2±54.9ng/L及92.5±26.3IU／ml）显著升高（P＜0．05）。缓解期哮喘患者sICAM-1和IgE较急性发作期明显下降。结论血液中sICAM-1与IgE一道参与了支气管哮喘的发病过程，因此，检测sICAM－1水平对急性发作期支气管哮喘存在与否具有重要意义。
Objective To further explore the pathogenesis of bronchial asthma. Methods Serum levels of soluble intercellular adhesion molecule (sICA-1) and IgE in 30 patients with bronchial asthma attack, 20 patients with remission, and 20 healthy controls were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) Level. Results The sICAM-1 and IgE of patients with bronchial asthma were 282.7 ± 79.5 (ng / L), 205.6 ± 64.7 (ng / L) and 359.1 ± 107.8, 236.2 ± 64.5 (IU / ml) Control (163.2 ± 54.9 ng / L and 92.5 ± 26.3 IU / ml) was significantly higher (P <0.05). SICAM-1 and IgE in remission patients were significantly lower than those in acute episode. Conclusion sICAM-1 and IgE are involved in the pathogenesis of bronchial asthma. Therefore, it is of great significance to detect the presence or absence of sICAM-1 in bronchial asthma during acute exacerbation.