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氨茶碱是一种经典的支气管扩张剂,近年来已被广泛用于治疗高原肺水肿(High altitude pulmonary edema,HAPE),其治疗机理主要包括扩张支气管、降低缺氧性肺动脉高压、增强膈肌功能、拮抗脂质过氧化(LPO)及缺氧引起的肺部血管炎症反应、强心利尿、清除黏液消除肺部湿罗音等。氨茶碱对气管和血管平滑肌的双重扩张作用是一般治疗HAPE的血管扩张剂所不具备的,氨茶碱在HAPE的治疗中具有其独特的优势效应。
Aminophylline is a classic bronchodilator, which has been widely used in the treatment of high altitude pulmonary edema (HAPE) in recent years. Its therapeutic mechanism mainly includes expanding the bronchus, reducing hypoxic pulmonary hypertension and enhancing diaphragmatic function , Antagonize lipid peroxidation (LPO) and hypoxia-induced pulmonary vascular inflammation, cardiac diuretic, mucus to clear the lungs wet rales and so on. Aminophylline on the trachea and vascular smooth muscle double-dilatation is generally not treated with vasodilators HAPE, aminophylline in the treatment of HAPE has its unique advantages.