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目的探讨血药浓度监测在儿童癫痫规范化治疗中的临床意义。方法采用高效液相色谱法对我院192例癫痫患儿使用丙戊酸钠或苯巴比妥后的血药浓度进行了576次监测,对监测结果进行分析与评价。结果服用丙戊酸钠患儿456例次,其血药浓度达到有效范围的占51.97%,服用苯巴比妥患儿120例次,其血药浓度达到有效范围的占45.0%。结论血药浓度监测对于规范化治疗儿童癫痫临床用药的科学合理化、安全有效性有重要价值。
Objective To investigate the clinical significance of plasma concentration monitoring in the standardization of children with epilepsy. Methods The plasma concentrations of sodium valproate or phenobarbital in 192 children with epilepsy in our hospital were monitored by HPLC. The monitoring results were analyzed and evaluated. Results 456 cases of children taking sodium valproate, the plasma concentration reached the effective range of 51.97%, taking 120 cases of phenobarbital children, the plasma concentration reached the effective range of 45.0%. Conclusion The monitoring of plasma concentration is of great value for the scientific rationalization and safety and effectiveness of clinical treatment of children epilepsy.