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端粒是真核细胞染色体末端的特有结构 ,由串联重复的DNA序列和特异蛋白构成 ,这些序列在进化上高度保守 ,能维持染色体的稳定和完整。端粒酶是RNA和蛋白质组成的复合体 ,其核心序列是拷贝端粒DNA的模板。端粒酶在肿瘤的发生、发展中具有重要作用。研究端粒酶的活性表达及其调节和作用机理 ,对肿瘤的早期诊断和治疗有着重要的意义
Telomeres are unique structures at the end of the chromosome of eukaryotes and consist of tandemly repeated DNA sequences and specific proteins that are evolutionarily conserved to maintain chromosomal stability and integrity. Telomerase is a complex of RNA and protein whose core sequence is a template for the copy of telomeric DNA. Telomerase plays an important role in tumorigenesis and development. To study the activity of telomerase and its regulation and mechanism of action is of great significance in the early diagnosis and treatment of tumors