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目的:评估TPF(紫杉醇、顺铂、氟尿嘧啶)诱导化疗对局部晚期可切除口腔鳞癌患者生活质量的影响。方法 :选择2008年3月—2010年12月收治的临床Ⅲ期或ⅣA期原发口腔鳞癌患者256例,随机分为2组,每组128例;试验组为TPF诱导化疗加手术和术后放疗,对照组为手术加术后放疗。运用EORTC QLQ-C30和QLQ-HN35量表对所有患者的生活质量进行评估,采用SAS 9.2软件包对数据进行统计学分析。结果:256例入组患者中,243例患者至少有1张有效问卷。QLQ-C30的总健康状况和QLQ-HN35的疼痛、吞咽、感觉、语言、进食、社交障碍、性功能减退在试验组和对照组之间无显著差异。治疗后3个月,试验组患者的开口问题比对照组严重,但总体评价显示组间差异无统计学意义(P>0.05)。结论:TPF诱导化疗对局部晚期口腔鳞癌患者的生活质量无显著影响。
Objective: To evaluate the effects of TPT (paclitaxel, cisplatin, fluorouracil) -induced chemotherapy on quality of life in patients with locally advanced resectable oral squamous cell carcinoma. Methods: Two hundred and sixty-six patients with primary stage Ⅲ or ⅣA primary oral squamous cell carcinoma who were admitted to our hospital from March 2008 to December 2010 were randomly divided into 2 groups (n = 128). The experimental group was treated with TPF induction chemotherapy After radiotherapy, the control group was surgery plus radiotherapy. All patients were evaluated for quality of life using the EORTC QLQ-C30 and QLQ-HN35 scales, and data were statistically analyzed using the SAS 9.2 software package. Results: Of the 256 enrolled patients, 243 patients had at least one valid questionnaire. The overall health status of QLQ-C30 and pain, swallowing, feeling, language, eating, social disturbance, and sexual dysfunction of QLQ-HN35 were not significantly different between the experimental group and the control group. At 3 months after treatment, the opening of the test group patients was more serious than the control group, but the overall evaluation showed no significant difference between the groups (P> 0.05). Conclusion: TPF induced chemotherapy had no significant effect on quality of life in patients with locally advanced oral squamous cell carcinoma.