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观察不同浓度双异丙酚对豚鼠、大鼠心室乳头肌收缩活动的影响，并探讨其作用机制。结果表明：①１０μｍｏｌ／Ｌ以上浓度即可明显抑制豚鼠心室乳头肌收缩，使收缩最大张力（Ｐ０）和张力上升最大速率（ｄＴ／ｄｔｍａｘ）分别降至对照值的４３．０％和４５．４％，且呈明显浓度依赖性；但双异丙酚对大鼠心室乳头肌收缩无明显影响，提示双异丙酚对动物心室乳头肌的抑制具有种属差异。②双异丙酚对豚鼠休息后刺激引发的第一次收缩（Ｂ１）和心肌休息后恢复时间（ＲＴ）无明显影响，而对休息后刺激引发的第二次收缩（Ｂ２）有明显抑制作用，提示双异丙酚对豚鼠心室乳头肌的抑制作用可能是通过阻断Ｃａ通道，抑制Ｃａ内流实现的。
The effects of different concentrations of propofol on contractile activity of guinea pig and rat papillary muscles were observed and the mechanism of action was discussed. The results showed that: (1) At a concentration of above 10μmol / L, contractility of papillary muscles of guinea pigs was significantly inhibited and the maximal contractive (P0T) and maximal rate of dT / dtmax decreased to 43.0% and 45.4% , And showed a significant concentration-dependent; but propofol did not affect the contractility of ventricular papillary muscle in rats, suggesting that propofol on ventricular papillary muscle inhibition with species differences. ② Propofol had no significant effect on the first contractions (B1) induced by resting and the recovery time (RT) after resting in guinea pigs but significantly inhibited the second contraction (B2) induced by resting stimuli in resting guinea pigs , Suggesting that propofol on guinea pig ventricular papillary muscle inhibition may be blocked by Ca channel inhibition of Ca influx to achieve.