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目的探讨结直肠癌并肝转移患者介入治疗与姑息化疗的临床疗效。方法对结直肠癌肝转移灶18例行肝动脉介入栓塞化疗,10例行单纯全身化疗,均采用FOLFOX4方案(奥沙利铂85 mg/m2,静脉滴注2 h,第1天;亚叶酸钙200 mg/m2,静脉滴注2 h,第1～2天;5-氟尿嘧啶400 mg/m2,于亚叶酸钙滴完后静脉滴注10 min,第1～2天;5-氟尿嘧啶600 mg/m2,持续静脉滴注22 h,第1～2天;每2周重复,4周为一个周期)。结果患者1、2、3年生存率介入组分别为33.83%、11.28%和0;单纯化疗组为32.9%、10.69%和0。两者生存期比较差异无统计学意义,P>0.05。结论介入治疗与姑息化疗疗效比较差异无统计学意义,需根据病情进一步改进治疗方案。
Objective To investigate the clinical effects of interventional therapy and palliative chemotherapy in patients with colorectal cancer and liver metastasis. Methods Eighteen patients with hepatic metastases of colorectal cancer undergoing hepatic artery interventional chemoembolization and 10 patients undergoing simple systemic chemotherapy were treated with FOLFOX4 regimen (oxaliplatin 85 mg / m2, intravenous drip 2 h, day 1; leucovorin Calcium 200 mg / m2, intravenous drip 2 h, 1 to 2 days; 5-Fluorouracil 400 mg / m2, intravenous infusion of leucovorin after 10 min, 1 to 2 days; 5-fluorouracil 600 mg / m2, continuous intravenous infusion of 22 h, 1 to 2 days; repeated every 2 weeks, 4 weeks for a cycle). Results The 1, 2, 3-year survival rates of the intervention group were 33.83%, 11.28% and 0, respectively; those in the simple chemotherapy group were 32.9% and 10.69%, respectively. There was no significant difference in survival between the two groups, P> 0.05. Conclusion There is no significant difference between the interventional treatment and palliative chemotherapy. The treatment plan should be further improved according to the condition.