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为了了解河南省丁型肝炎病毒（ＨＤＶ）的人群感染情况，从１９９１～１９９３年对河南省十三个地区１１８２例ＨＢｓＡｇ阳性的各型乙肝病人及无症状ＨＢｓＡｇ携带者血清标本进行ＨＤＡｇ、抗－ＨＤＶ和ＩｇＭ－抗－ＨＤＶ三项标志检测。结果表明，河南省人群ＨＤＡｇ、抗－ＨＤＶ、ＩｇＭ－抗－ＨＤＶ的总感染率分别为３．０％、３．５％、３．５％、８．１％。由此可见，河南地区确实存在有ＨＤＶ感染，各地区感染率略有差别。从ＨＤＶ感染率的年龄和性别分布来看，女性组（１０．１％）略高于男性组（７．３％），６０岁以上年龄组（２１．４％）高于其它各年龄组。通过对各型乙肝病人血清标本中的ＨＤＶ标志检测发现，携带者、急性乙肝、慢活肝、慢迁肝、肝硬化、重肝组病人ＨＤＶ总感染率依次为８．７％、１．６％、７．７％、６．３％、１１．９％、０．０％，其中以肝硬化组病人ＨＤＶ感染率最高。本研究结果证明ＨＤＶ和ＨＢＶ确实存在有重叠和重复感染，ＨＤＶ的感染对ＨＢＶ感染的慢性化和肝硬化的形成起一定的促进作用，在临床上应引起足够重视。
In order to understand the crowd infection of hepatitis D virus (HDV) in Henan province, from 11198 HBsAg positive HBsAg positive HBsAg carriers in 13 districts of Henan Province from 1991 to 1993, HDV and IgM-anti-HDV three markers. The results showed that the total infection rates of HDAg, anti-HDV and IgM-anti-HDV in Henan were 3.0%, 3.5%, 3.5% and 8.1% respectively. Thus, there is indeed a HDV infection in Henan Province, a slight difference in infection rates in various regions. According to the age and sex distribution of HDV infection rate, the female group (10.1%) was slightly higher than the male group (7.3%), while the group over 60 years old (21.4%) was higher than the other age groups. Through the detection of HDV markers in serum samples of various types of hepatitis B patients, the total HDV infection rates of carriers, acute hepatitis B, slow-living liver, slow-moving liver, cirrhosis and severe liver cancer were 8.7% and 1.6 %, 7.7%, 6.3%, 11.9%, 0.0%, of which patients with cirrhosis of the highest HDV infection rate. The results of this study demonstrate that HDV and HBV do indeed have overlapping and recurrent infections. HDV infection may play a role in promoting the development of chronic HBV infection and cirrhosis, which should be paid more attention in clinic.