The left ventricular radial strain in the inner and outer layers was evaluated by using two-dimensional speckle tracking imaging(2DS).Twenty-five piglets were studied.The short axis views were acquired.Peak systolic radial strain was measured from 6 circumferential points related to 6 standard segments in the inner and outer layers respectively using 2DS methods.The peak positive first derivative(dp/dt) of left ventricular pressure was compared to the radial strain from 2DS.The inner band showed higher peak radial strain values as compared to the outer band at all of the segments(P<0.0001),but the differences had significance just in anteroseptal,posterior,inferior and septal segments(P<0.05).Good correlation could be found between radial strain of inner and outer layers and peak dp/dt(P<0.001).These preliminary results showed that the degree of local deformation or wall thickening of the ventricular wall in its inner layer was more obvious than its outer layer.It is suggested that the 2DS technique is useful and sensitive for better understanding the regional and global myocar-dial motion and its relationship to the complex architecture of myocardium. The left ventricular radial strain in the inner and outer layers was evaluated by using two-dimensional speckle tracking imaging (2DS). Twenty-five piglets were studied. The short axis views were acquired. Peak systolic radial strain was measured from 6 circumferential points related to 6 standard segments in the inner and outer layers respectively using 2DS methods. peak positive first derivative (dp / dt) of left ventricular pressure was compared to the radial strain from 2DS. inner circle showed higher peak radial strain values ​​as compared to the outer band at all of the segments (P <0.0001), but the differences had significance just in anteroseptal, posterior, inferior and septal segments (P <0.05) .Good correlation could be found between radial strain of inner and outer layers and peak The preliminary results showed that the degree of local deformation or wall thickening of the ventricular wall in its inner layer was more obvious than its outer layer. It is suggested that the 2DS technique is useful and sensitive for better understanding of the regional and global myocar-dial motion and its relationship to the complex architecture of myocardium.