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高血压病是严重威胁人类健康和生命的常见疾病。有研究证实人类的高血压患者存在血管内皮功能减退,后者又加速了高血压靶器官的损害。目前认为血管内皮细胞所分泌的一氧化氮(NO)/内皮素(ET-1)的失衡在高血压的发生、发展中起重要作用。内皮细胞是“内皮-高血压-心血管事件”链的始动因子和载体[1]。
Hypertension is a common disease that seriously threatens human health and life. Studies have confirmed that human hypertensive patients have vascular endothelial dysfunction, which in turn accelerated the damage of target organs of hypertension. At present, it is thought that the imbalance of nitric oxide (NO) / endothelin (ET-1) secreted by vascular endothelial cells plays an important role in the occurrence and development of hypertension. Endothelial cells are the initiating factor and carrier of the “endothelial-hypertensive-cardiovascular event” chain [1].