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目的观察纳洛酮治疗头孢哌酮钠致双硫醒样反应的疗效。方法选取2004年4月至2006年10月在解放军3303厂医院63例静滴头孢哌酮钠期间坎酒后发生双硫醒样反应的患者,随机分成治疗组和对照组。治疗组单用纳洛酮,对照组用常规方法治疗。观察两组患者症状消失、体征恢复正常的时间。结果治疗组症状消失、体征恢复正常的时间为(2.78±1.07)h,对照组症状消失、体征恢复正常的时间为(7.83±1.97)h,两者差异有显著性意义(P<0.01)。结论纳洛酮治疗双硫醒样反应可明显促进症状消失、体征恢复正常,缩短疗程。疗效优于常规方法。
Objective To observe the curative effect of naloxone on cefoperazone sodium induced by bisulfite-like reaction. METHODS: From April 2004 to October 2006, 63 patients with seizure-wake reaction after oral administration of cefoperazone sodium in 3303 hospital of PLA were randomly divided into treatment group and control group. The treatment group was naloxone alone, and the control group was treated by conventional methods. Two groups of patients were observed symptoms disappeared, the signs returned to normal time. Results The symptoms of the treatment group disappeared and the signs returned to normal (2.78 ± 1.07 h). The symptoms of the control group disappeared and the signs returned to normal (7.83 ± 1.97 h). There was a significant difference between the two groups (P <0.01). Conclusion Naloxone treatment of two sulfur wake-like reaction can significantly promote symptoms disappeared, signs returned to normal, shorten the course of treatment. Efficacy than conventional methods.