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目的 研究术前和术后辅助性肝动脉栓塞化疗对肿瘤直径为8cm以上的巨块型肝癌病人切除术后的影响。方法 采用病例对照研究的方法,将本所1995~1998年的病例资料,用Kaplan-Meier方法研究单纯切除术病人,术后辅助性肝动脉栓塞化疗,术前辅助性肝动脉栓塞化疗病人生存曲线。Log-rank方法比较各生存曲线的差别。结果 单纯切除组病人、术后辅助性肝动脉栓塞化疗、和术前辅助性肝动脉栓塞化疗病人的中位生存期分别为17.0月,33.0月,和49.0月(P=0.011)。结论 提示术前辅助性肝动脉栓塞化疗效果优于术后辅助性肝动脉栓塞化疗的结果。对于肿瘤直径在8cm的肝癌,应该在术前或术后给予辅助性肝动脉栓塞化疗。
Objective To study the effect of preoperative and postoperative adjuvant hepatic arterial chemoembolization on the resection of giant-type hepatocellular carcinoma patients with a tumor diameter of 8 cm or more. Methods A case-control study was conducted in our hospital from 1995 to 1998 with Kaplan-Meier method to study the survival curves of patients undergoing simple resection, postoperative adjuvant hepatic arterial chemoembolization and preoperative adjuvant hepatic arterial chemoembolization . Log-rank method to compare the difference between the survival curves. Results The median survival time of the resection group, postoperative adjuvant hepatic arterial chemoembolization and preoperative adjuvant hepatic arterial chemoembolization were 17.0 months, 33.0 months and 49.0 months respectively (P = 0.011). Conclusions suggest that preoperative adjuvant hepatic arterial chemoembolization is superior to postoperative adjuvant hepatic arterial chemoembolization. For the tumor diameter of 8cm of liver cancer, should be given before surgery or after adjuvant hepatic arterial chemoembolization.