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目的观察中药复方芪术汤联合高效抗反转录病毒治疗(HAART)对艾滋病(AIDS)病人的临床疗效及安全性。方法收集符合抗病毒标准的AIDS病人共74例,将其分为三组:单用HAART组30例,唐草片联合HAART组22例,复方芪术汤联合HAART组22例。每组均治疗6个月,观察3个月及6个月时CD+4T淋巴细胞(简称CD4细胞)计数、中医证候疗效及治疗过程中有无不良反应。结果唐草片联合HAART组治疗6个月后,对比HAART组CD4细胞差异有统计学意义(P<0.05);复方芪术汤联合HAART治疗6个月后,对比HAART组CD4细胞差异有统计学意义(P<0.05);复方芪术汤与唐草片两组之间差异无统计学意义(P>0.05)。唐草片组、复方芪术汤组治疗3个月、6个月后,对比单用HAART组,中医症状体征积分差异均有统计学意义(P<0.05或P<0.01)。其中,唐草片组、复方芪术汤组组间差异无统计学意义。唐草片组、复方芪术汤组治疗后3个月和6个月,对比单用HAART组,中医证候疗效差异均有统计学意义(P<0.01);两组之间差异无统计学意义。三组病人治疗中血常规、肝功能差异均无统计学意义(P>0.05)。结论复方芪术汤联合HAART治疗AIDS病人,对改善中医证候疗效、提高CD4细胞计数有一定作用,与唐草片联合HAART疗效相当。相比于单用HAART治疗方案,复方芪术汤联合HAART无明显不良反应,安全可靠。
Objective To observe the clinical curative effect and safety of traditional Chinese medicine compound Qizhu Decoction combined with highly effective antiretroviral therapy (HAART) on AIDS patients. Methods A total of 74 AIDS patients were collected and divided into three groups: 30 cases in the HAART group, 22 cases in the HAART group and 22 cases in the HAART group. Each group was treated for 6 months. The counts of CD + 4T lymphocytes (referred to as CD4 cells) at 3 months and 6 months were observed. The curative effect of TCM syndromes and whether there were any adverse reactions in the course of treatment were observed. Results Compared with HAART group, the percentage of CD4 cells in HAART group was significantly lower than that in HAART group (P <0.05). After 6 months’ treatment with Fufang Qizhu decoction combined with HAART, the difference of CD4 cell count between HAART group and control group was statistically significant (P <0.05). There was no significant difference between Fufang Qizhu Decoction and Tangcao Tablet (P> 0.05). Compared with HAART alone group, the scores of symptom and symptom in TCM group were significantly different (P <0.05 or P <0.01) after 3 months and 6 months of treatment with Tangcao Tablet and Compound Qizhu Decoction. Among them, Tang Heda group, compound Qizhu Decoction group no significant difference between groups. Compared with HAART group alone, the effect of traditional Chinese medicine syndromes in both Tangcao Tablet and Compound Qizhu Decoction group were statistically significant (P <0.01). There was no significant difference between the two groups . Three groups of patients in the treatment of blood, liver function differences were not statistically significant (P> 0.05). Conclusion Fufang Qizhu Decoction combined HAART treatment of AIDS patients, to improve the efficacy of traditional Chinese medicine syndrome, improve CD4 cell count has a certain effect, and the efficacy of Tang Huan HAART combined with HAART. Compared with the HAART treatment alone, Fufang Qizhu Decoction combined HAART no obvious adverse reactions, safe and reliable.