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目的观察初发2型糖尿病患者的血清RegⅠα水平,并分析其与其他临床指标的相关性,探讨其可能的临床意义。方法经口服葡萄糖耐量试验(oral glucose tolerance test,OGTT)入选110名正常糖耐量(normal glucose tolerance,NGT)和46名2型糖尿病患者(type 2 diabetes mellitus,T2DM)。酶联免疫吸附测定测定血清RegⅠα和胰岛素、C反应蛋白(hs-CRP)、人脂肪细胞脂肪酸结合蛋白(A-FABP)、脂联素等。结果NGT组和T2DM组的血清RegⅠα水平无显著差异[(626.82±359.60)ng/mLvs(610.11±326.01)ng/mL,P=0.788];在所有研究对象中,血清RegⅠα水平与年龄正相关,同时与腰臀比(WHR)、A-FABP、hs-CRP呈正相关,与高密度脂蛋白(HDL-C)呈负相关,与空腹血糖(FPG)和OGTT 2 h血糖和胰岛素水平无明显相关性。校正年龄因素后,RegⅠα水平与A-FABP正相关,与HDL-C负相关。但在T2DM组,RegⅠα和A-FABP、HOMA-B成正相关(r值分别为0.428,0.424;P值分别为0.042,0.044),和FPG、糖化血红蛋白1(HbA1c)呈负相关(r分别为-0.525,-0.425,P值分别为0.01,0.043)。结论与NGT相比,初发T2DM患者血清RegⅠα水平没有明显差异;在T2DM患者血清RegⅠα与胰岛功能和血糖水平有一定的关系,提示RegⅠα有可能参与T2DM的β细胞代偿,有可能是评价胰岛功能的指标之一。
Objective To observe the serum level of RegⅠα in patients with newly diagnosed type 2 diabetes mellitus and to analyze its correlation with other clinical indexes and to explore its possible clinical significance. Methods Totally 110 normal glucose tolerance (NGT) and 46 type 2 diabetes mellitus (T2DM) patients were enrolled in the oral glucose tolerance test (OGTT). Serum RegⅠα and insulin, C-reactive protein (hs-CRP), human adipocyte fatty acid-binding protein (A-FABP) and adiponectin were determined by enzyme linked immunosorbent assay. Results There was no significant difference in the serum RegⅠα levels between NGT group and T2DM group (626.82 ± 359.60 ng / mL vs 610.11 ± 326.01 ng / mL, P = 0.788). In all the subjects, serum RegⅠα level was positively correlated with age, It also had a positive correlation with WHR, A-FABP and hs-CRP, negatively correlated with HDL-C and no significant correlation with fasting blood glucose (FPG) and blood glucose and insulin levels at 2 h of OGTT Sex. After adjusting for age, RegⅠα level was positively correlated with A-FABP and negatively correlated with HDL-C. In T2DM group, there was a positive correlation between RegⅠα, A-FABP and HOMA-B (r = 0.428, 0.424, P = 0.042,0.044, respectively) and negative correlation with FPG and HbA1c -0.525, -0.425, P values were 0.01, 0.043, respectively). Conclusions Compared with NGT, the serum level of RegⅠα in T2DM patients has no significant difference. In the patients with T2DM serum RegⅠα has a certain relationship with islet function and blood glucose level, suggesting that RegⅠα may be involved in β-cell compensatory in T2DM. One of the indicators of function.