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目的 :研究血浆血栓调节蛋白 (TM)水平在糖尿病中的意义。方法 :用酶联免疫吸附试验检测 5 2例 2型糖尿病病人的 TM水平。依照动脉粥样硬化病变的范围将病人分成 3组 :1组 ,糖尿病未并发闭塞性动脉粥样硬化性疾病组 ;2组 ,糖尿病并发一种闭塞性动脉粥样硬化性疾病组 ;3组 ,糖尿病并发两种或两种以上闭塞性动脉粥样硬化性疾病组。结果 :糖尿病组及它的各亚组的 TM水平均比对照组显著增加 (P <0 .0 1) ;1组、2组、3组的 TM水平依次增高 ,且各组间比较具有显著差异 (P <0 .0 1)。结论 :用血浆可溶性 TM水平评价糖尿病病人的动脉粥样硬化病变范围具有很大价值。
Objective: To investigate the significance of plasma thrombomodulin (TM) level in diabetes. Methods: The TM levels of 52 patients with type 2 diabetes mellitus were detected by enzyme-linked immunosorbent assay. The patients were divided into 3 groups according to the range of atherosclerotic lesion: group 1, group with diabetes without occlusive atherosclerotic disease; group with diabetes with occlusive group with atherosclerotic disease; group 3 with diabetes, Diabetes complicated by two or more groups of occlusive atherosclerotic disease. Results: The levels of TM in diabetes mellitus group and its subgroups were significantly higher than those in control group (P <0.01). The TM levels in groups 1, 2 and 3 were successively higher than those in control group (P <0. 01). Conclusion: It is of great value to evaluate the range of atherosclerotic lesions in diabetic patients by using plasma soluble TM level.