论文部分内容阅读
氨甲喋呤(MTX)广泛用于治疗银屑病。1975年据估计在美国有25000名银屑病患者用MTX治疗,近来调查,有52%美国皮科医生用它治疗银屑病。本文作者对MTX的适应症,用法及并发症作了简要的综述。关于MTX对肝的毒性,由于用药方案,总剂量的不同以及素质因素如酒精中毒、糖尿病和肥胖病等影响,很难估计患者发生危险的确定的百分比。根据至今积累的大量资料MTX对肝的毒性有如下特点: 1.间歇投药方案比连续方案较少产生肝中毒反应。看来是肝细胞接触药物的时间长短,而不是每次接触药物的浓度决定此中毒反应。因此,每周口服一次或36小时内分次服比每日小量连服毒性要
Methotrexate (MTX) is widely used in the treatment of psoriasis. In 1975, an estimated 25,000 patients with psoriasis were treated with MTX in the United States. In a recent survey, 52% of American picoids used it to treat psoriasis. The author of the MTX indications, usage and complications made a brief review. With regard to the toxic effects of MTX on the liver, it is difficult to estimate the exact percentage of patients at risk due to drug regimens, differences in total doses, and quality factors such as alcoholism, diabetes and obesity. According to a large number of data accumulated so far MTX liver toxicity has the following characteristics: 1. Intermittent drug administration program less than the continuous program of liver toxicity. It appears that the duration of exposure of the hepatocytes to the drug, rather than the concentration of each exposure to the drug, determines the toxic response. Therefore, oral once weekly or 36 hours less than the daily dose of sub-serving to take a small amount of toxicity