本文报告庆大霉素引起一过性血尿10例。男8例,女2例。最小6个月,最大10岁,平均5岁半。常规剂量8例,愈量2例。全部在肌注后1～2d内出现血尿,停药2～4d内镜下血尿消失,并排除肾脏或其他疾病所致血尿。其中肉眼血尿6例,镜下血尿4例。伴随症状:眼睑浮肿4例,乏力6例,尿痛4例,尿急3例,尿频2例,腰困2例。做尿培养6例均阴性。查肾功6例,5例正常,1例BUN9mmol/L。随访5例6个月至1年,生长发育正常。尿检正常。 庆大霉素价格低廉,使用方便,常见滥用,本组6例呼吸道感染及4例腹泻均不宜首选庆大霉素肌注。该药致急性肾衰屡见报道,而致一过性血尿报告少见。文献认为该药肾毒性损害主要在近曲小管并有一定蓄积作用,其肾毒性与组织药物的浓度有关。本组8例用药在常规范围,血尿为一过性,未见肾功损害,可能与 This article reports 10 cases of transient hematuria caused by gentamicin. 8 males and 2 females. A minimum of 6 months, a maximum of 10 years old, an average of 5 years and a half. Conventional dose in 8 cases, the more the amount of 2 cases. All within 1 ~ 2d after intramuscular hematuria, discontinuation of 2 ~ 4d endoscopic hematuria disappeared, and rule out the kidney or other diseases caused by hematuria. Including gross hematuria in 6 cases, 4 cases of microscopic hematuria. Accompanied with symptoms: 4 cases of eyelid edema, fatigue in 6 cases, 4 cases of dysuria, urgency in 3 cases, urinary frequency in 2 cases, 2 cases of lumbar. 6 cases of urinary culture were negative. Check renal function in 6 cases, 5 cases were normal, 1 case BUN9mmol / L. Follow-up of 5 cases 6 months to 1 year, normal growth and development. Urinalysis is normal. Gentamicin cheap, easy to use, common abuse, the group of 6 cases of respiratory tract infection and 4 cases of diarrhea should not be preferred gentamicin intramuscular injection. The drug is frequently reported acute renal failure, and a transient hematuria report rare. Literature that the drug nephrotoxicity damage mainly in the proximal convoluted tubule and have a certain accumulation, the nephrotoxicity and tissue drug concentration. The group of 8 cases of medication in the conventional range, hematuria as a transient, no renal damage, may be associated with