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观察性研究表明，盐皮质激素可以影响胰岛素抵抗，并且这种作用与种族、血压或体质指数无关。盐皮质激素导致胰岛素抵抗的可能机制包括降低胰岛素受体基因转录、增强胰岛素受体底物降解、干扰胰岛素信号转导通路、降低血清脂联素水平及增加氧化应激水平和炎性因子等。动物模型实验已经证明了应用盐皮质激素受体拮抗剂有改善胰岛素抵抗的作用。“,”Observational studies have shown mineralocorticoid can affect insulin resistance irrespective of race,blood pressure or body weight.Potential mechanisms by which mineralocorticoid may contribute to insu-lin resistance include a decreased transcription of the insulin receptor gene,increased degradation of insulin receptor substrates, interference with insulin signaling mechanisms, decreased adiponectin production and increased oxidative stress and inflammation.Advantages of mineralocorticoid receptor antagonists on insulin resistance have been demonstrated in animal models.