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目的:从临床输血应用的角度,指导对稀有Rh血型的保存与实用型稀有血型库的建立。方法:对2000年~2006年的Rh阴性配血样本进行抗体分析,对1999年4月~2006年9月检出RhD阴性无偿献血者进行D抗原检测和DDel血型的筛选,及对其他Rh血型抗原检测。结果:在364例Rh阴性配血样本中,有抗-D抗体36例,抗-E20例,抗-c14例,抗-c、E9例,抗-C4例,抗-e10例,抗-D、E2例,抗-D、c4例;在1215名RhD阴性的A、B、O和AB血型献血者中,Rh血型抗原表现型以dccee(51.60%)和dCcee(31.52%)居多,其次为dccEe和dCCee表现型,未见dCCEE和dCcEE表现型。1999年4月~2006年8月共查出Du50人;在2005年5月~2006年1月的225名初筛RhD阴性献血者中共检出DDel型13人,所占比例为5.8%。结论:把O型的dccEE和dC-Cee表型红细胞,在工作中发现后及时冻存并在临床对应使用,在建立实用型稀有血型库、解决临床对特殊血型的需求具有实际的应用意义。
Objective: To guide the establishment of a rare Rh blood group and a practical rare blood bank from the perspective of clinical blood transfusions. Methods: Antibody analysis was performed on Rh-negative blood samples from 2000 to 2006. D-antigen detection and DDel blood type screening for RhD-negative unpaid blood donors from April 1999 to September 2006 were performed, as well as for other Rh blood types. Antigen detection. RESULTS: Of the 364 Rh negative matched blood samples, 36 were anti-D antibodies, 20 were anti-E, 14 were anti-c, 19 were anti-c, and 9 were E9, 10 were anti-C4, and 10 were anti-D. E2 cases, anti-D, c4 cases; Among 1215 RhD-negative A, B, O, and AB blood donors, the Rh blood group antigen phenotype was dccee (51.60%) and dCcee (31.52%), followed by The dccEe and dCCee phenotypes showed no dCCEE and dCcEE phenotypes. From April 1999 to August 2006, a total of Du50 people were detected; of the 225 initially screened RhD-negative blood donors from May 2005 to January 2006, 13 were classified as DDel, accounting for 5.8%. Conclusion: The Occidental dccEE and dC-Cee phenotype erythrocytes were found in the work and then frozen in time and used in clinical applications. It is of practical significance to establish a practical and rare blood group library to solve the clinical needs for special blood types.