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选择159例2型糖尿病患者,根据B超测得的IMT分为颈动脉血管病变组(a组)及颈动脉无血管病变组(b组);股动脉血管病变组(A组)及股动脉无血管病变组(B组),分别检测两组空腹血糖(FBG)、糖化血红蛋白(HbA1c)、纤维蛋白原(Fib)、D-二聚体(D-D)、Hcy、IMT等指标,并进行相关性分析。结果:a组的年龄、Fib、D-D、IMT、Hcy与b组比较差异有统计学意义(P<0.05),股动脉与颈动脉结果相似;颈、股动脉IMT均与年龄、病程、Fib、Hcy呈正相关(P<0.05);多元线性逐步回归分析显示年龄、Hcy均与CIMT及FIMT独立相关。结论:2型糖尿病颈、股动脉内膜中层厚度均与Hcy密切相关,监测Hcy有助于早期预测糖尿病血管病变。
One hundred and ninety-nine patients with type 2 diabetes mellitus were divided into three groups according to B-IMT: carotid artery disease group (group A) and carotid artery disease group (group b); femoral artery vascular disease group (group A) and femoral artery (Group B), FBG, HbA1c, fibrinogen (Fib), D-dimer (DD), Hcy, IMT and other indexes of two groups were detected and correlated Sexual analysis. Results: The age, Fib, DD, IMT and Hcy in group a were significantly different from those in group b (P <0.05). The results of femoral and carotid arteries were similar. The IMT of neck and femoral artery were significantly correlated with age, Hcy (P <0.05). Multivariate linear stepwise regression analysis showed that age and Hcy were independently associated with CIMT and FIMT. Conclusion: The intima-media thickness of neck and femoral artery in type 2 diabetes mellitus are closely related to Hcy. Monitoring Hcy may be helpful for the early prediction of diabetic vascular disease.