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目的：探讨血浆同型半胱氨酸（Hcy）在血管性痴呆（VD）合并糖尿病患者中的变化及意义。方法采用循环酶法检测40例VD合并糖尿病患者、42例VD患者和40例健康对照者血浆中Hcy水平，分析在VD合并糖尿病患者中 Hcy 的变化。结果 VD组 Hcy 水平明显高于对照组，差异有统计学意义（P<0.05）。VD合并糖尿病组 Hcy水平明显高于对照组和VD组（P<0.05）。结论血浆 Hcy 在VD合并糖尿病患者中明显升高， Hcy是VD患者发生发展的危险因素。“,”Objective To investigate the plasma homocysteine (Hcy) in vascular dementia (VD) changes and significance in patients with diabetes mel itus. Methods By enzymatic cycling assay in 40 patients with VD complicated with diabetes mel itus, 42 patients with VD and 40 healthy controls the level of Hcy in plasma in patients with diabetes mel itus, analysis of changes in Hcy in the VD. Results The level of Hcy in group VD was significantly higher than that in the control group, the difference was statistical y significant (P < 0.05). Hcy VD with diabetes group was obviously higher than that in control group and VD group (P < 0.05).Conclusion Plasma Hcy in VD with increased significantly in patients with diabetes, Hcy is a risk factor for the occurrence and development of VD patients.