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目的探讨灯盏花素对肝纤维化大鼠的保护作用。方法将大鼠随机分为对照组、模型组、水飞蓟宾组和灯盏花素组,采用皮下注射四氯化碳造成大鼠肝纤维化模型,每周两次,连续8周。测定各组大鼠血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)活性、白蛋白(ALB)、总蛋白(TP)、总胆红素(TBIL)含量;观察肝的形态学变化。结果与对照组比较,模型组大鼠血清ALT、AST升高(P﹤0.05或P﹤0.01),ALB降低(P﹤0.01);肝细胞变性坏死明显,纤维组织明显增生;与模型组比较,水飞蓟宾和灯盏花素组血清ALT、AST降低(P﹤0.05),ALB升高(P﹤0.01或P﹤0.05);肝细胞变性、坏死及肝内纤维组织增生明显减轻;与水飞蓟宾组比较,灯盏花素组各项指标均未出现明显差异(P﹥0.05)。结论灯盏花素对肝纤维化大鼠具有保护作用。
Objective To investigate the protective effect of breviscapine on liver fibrosis in rats. Methods The rats were randomly divided into control group, model group, silybin group and breviscapine group. Rats were injected with carbon tetrachloride subcutaneously to induce hepatic fibrosis twice a week for 8 weeks. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) activity, albumin (ALB), total protein (TP) and total bilirubin (TBIL) Results Compared with the control group, the levels of ALT and AST in model group were significantly increased (P <0.05 or P <0.01), ALB was decreased (P <0.01), the degeneration and necrosis of hepatocytes were obvious and the proliferation of fibrous tissue was obvious. Compared with model group, The serum levels of ALT and AST in silybin and breviscapine group were significantly lower than those in silybin group (P <0.05 or P <0.01 or P <0.05), and liver cell degeneration, necrosis and intrahepatic fibrosis were significantly reduced. Compared with the control group, no significant difference was found between the indexes of breviscapine group (P> 0.05). Conclusion Breviscapine has a protective effect on liver fibrosis in rats.