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配制氯化鈉和葡萄糖注射液,目前普遍存在的二个問題,就是怎样由过濾操作除尽所有杂質以及加热灭菌后所产生的各种異物。这二个問題,不但有碍于制剂質量、而且大大影响了工作效率。我們从1953年秋开始进行配制氯化鈉和葡萄糖注射液以来,由于上述二个問題長时間的不能很好解决,虽在实际使用上沒有發生过任何不良反应,但与中国药典1953年版所規定的規格是不相容的。其次返工次数多,工作效率低,廢品有时竟达70%以上,因而浪費国家資財,影响供应,甚至会使工作失去信心。所以改良过濾操作和寻求加热灭菌后产生各种異物的原因和克服的方法,实为提高質量的重要关鍵。茲將我們研究和改进的結果,从几个主要环节方面总結报导,希望大家指导批評。
Preparation of sodium chloride and glucose injection, the two common problems, is how to remove all the impurities by filtration and heat sterilization after the various foreign objects. These two problems not only hinder the quality of preparations, but also greatly affect the work efficiency. Since the autumn of 1953, we started to formulate sodium chloride and glucose injection, since the above two problems can not be solved for a long time, although no adverse reactions have occurred in actual use, but with the provisions of the Chinese Pharmacopoeia 1953 edition The specifications are incompatible. Second, the number of rework, work efficiency is low, waste sometimes as high as 70%, thus wasting state assets, affecting the supply, or even lose confidence in the work. Therefore, to improve the filtering operation and to seek the cause of heating and sterilizing various foreign bodies and to overcome the method, in fact, an important key to improving the quality. We will summarize the results of our research and improvement from several main aspects and hope everyone will guide criticism.