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目的 探讨肝脏结节性再生性增生的临床病理特点及诊断要点和需进行鉴别诊断的疾病。方法 收集 9例肝脏结节性再生性增生 ,分析、总结其临床病史、病理改变特点。结果 肝脏结节性再生性增生是非肝硬化性门脉高压的一个重要原因 ,多与自身免疫疾病 ,恶性肿瘤或服用某些药物等有关。临床以门脉高压为主要表现 ,但肝功能正常或仅轻度异常。病理学检查肝脏内弥漫分布无纤维分隔的小的再生结节 ,其门静脉分支有不同程度阻塞性改变 ,提示本病形成与门静脉分支的局灶性阻塞致其所供应的部分肝组织的慢性缺氧有关。结论 肝脏结节性再生性增生有其特点 ,诊断时应与肝硬化、局灶结节性增生、肝细胞腺瘤等疾病鉴别。
Objective To investigate the clinical and pathological features of liver nodular regenerative hyperplasia and the main points of diagnosis and the diseases to be differentiated. Methods Nine cases of nodular regenerative hyperplasia were collected and analyzed. The clinical history and pathological changes were summarized. Results Liver nodular regenerative hyperplasia is an important cause of non-cirrhotic portal hypertension, and more associated with autoimmune diseases, malignant tumors or taking certain drugs. Clinical portal hypertension as the main performance, but normal liver function or only mild abnormalities. Pathological examination of diffuse distribution of the liver without fibrous separation of small regenerative nodules, the portal vein branches obstructive changes of varying degrees, suggesting that the formation of this disease and the portal vein branch of the focal obstruction caused by the supply of some chronic liver tissue defects Oxygen related. Conclusion Liver nodular regenerative hyperplasia has its own characteristics. It should be differentiated from cirrhosis, focal nodular hyperplasia and hepatocellular adenoma in the diagnosis.