论文部分内容阅读
急性HDV感染的血清学诊断是基于HDAg和/或抗-HD的测定。在HDV和HBV联合感染时,HDV标记往往呈一过性,而慢性HBsAg携带者重叠HDV时,多呈慢性感染并伴血清总抗-HD和IgM抗-HD阳性以及肝内HDAg。最近,应用分子杂交技术测定HDV感染患者的血清HDV RNA,旨在明确其临床意义以及观察与急性或慢性HDV感染的其他标记(如肝内HDAg和血清IgM抗-HD)的相互关系。
Serological diagnosis of acute HDV infection is based on the determination of HDAg and / or anti-HD. HDV markers tend to be transient in HDV and HBV co-infections, while chronic HBsAg carriers overlap with HDV and are mostly chronically infected with serum total anti-HD and IgM anti-HD positive and intrahepatic HDAg. Recently, the use of molecular hybridization to determine serum HDV RNA in HDV-infected patients was intended to clarify its clinical significance as well as to examine the interrelationship with other markers of acute or chronic HDV infection such as intrahepatic HDAg and serum IgM anti-HD.