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探讨血清神经元特异性烯酸酶（NSE）、血浆内皮素-l（ET-1）与新生儿缺氧缺血性脑病（HIE）预后的关系。方法分别用酶联免疫法和放射免疫法动态测定25例正常足月新生儿和59例足月HIE新生儿血清NSE浓度和血浆ET-1浓度（生后24小时内、第3天、第7天）。并于生后3个月、6个月用Gesell法进行神经发育检查。结果血清NSE、血浆ET-1浓度与新生儿HIE程度呈正相关；生后3天内NSE、ET-1浓度显著增高及第7天浓度持续不降者预后不良。结论生后第3天血清NSE与血浆ET-1浓度可早期预测新生儿HIE近期预后，NSE预测预后的特异性高于ET1，动态观察则预后价值更高，对临床早期干预以减少中枢神经系统后遗症的发生有重要指导意义。
To investigate the relationship between serum neuron specific enolase (NSE), plasma endothelin-1 (ET-1) and the prognosis of neonatal hypoxic-ischemic encephalopathy (HIE). Methods Serum concentrations of NSE and plasma concentrations of ET-1 in 25 normal term neonates and 59 full term HIE neonates were measured by enzyme-linked immunosorbent assay and radioimmunoassay respectively (within 24 hours after birth, day 3, day 7 day). And 3 months after birth, 6 months with Gesell method for neurodevelopmental examination. Results Serum levels of NSE and plasma ET-1 were positively correlated with the neonatal HIE. The levels of NSE and ET-1 were significantly increased within 3 days after birth and the prognosis was not significant at 7 days. Conclusions Serum NSE and plasma ET-1 concentration on the third day after birth can predict the short-term prognosis of neonates with HIE at an early stage. The predictive prognosis of NSE is more specific than that of ET1. The dynamic prognosis is more valuable in predicting the prognosis of neonates. Early intervention in clinical trials to reduce central nervous system The occurrence of sequelae has important guiding significance.