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目的研究HBsAg阴性乙型肝炎的临床转归和预后。方法回顾分析50例HBsAg阴性的乙型肝炎患者十年前后的乙肝二对半、HBVDNA、肝功能、B超的变化。结果十年后50例患者中仅6例出现过ALT升高(均<100U/L),3例和脂肪肝有关,3例因服用损肝药物所致,停药后ALT恢复正常。50例患者均存活,肝功能基本正常,1例HBVDNA1.4E+03copies/ml.49例HBVDNA<1.0E+03copies/ml。10例表现为慢性肝炎,3例为脂肪肝1例为肝硬化,未发现肝癌。结论HBsAg阴性的乙型肝炎临床症状,肝功能变化,病情发展缓慢,十年的临床转归和预后较好。
Objective To study the clinical outcome and prognosis of HBsAg-negative hepatitis B patients. Methods A retrospective analysis of 50 cases of HBsAg-negative hepatitis B ten years ago, two pairs of HBsAg, HBVDNA, liver function, B ultrasound changes. Results Only 10 out of the 50 patients ten years later, ALT increased (all <100 U / L), 3 were associated with fatty liver, and 3 were due to liver injury. ALT returned to normal after treatment. All 50 patients survived with normal liver function, and HBVDNA1.4E + 03copies / ml in 1 case had HBVDNA <1.0E + 03copies / ml in 49 cases. 10 cases showed chronic hepatitis, 3 cases of fatty liver, 1 case of cirrhosis, liver cancer was not found. Conclusion HBsAg-negative hepatitis B clinical symptoms, changes in liver function, slow progression of the disease, clinical outcomes and prognosis of 10 years is good.