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目的:探讨糖化血红蛋白(HbAlc)在急性脑梗死(ACI)中的意义。方法:回顾性分析急性动脉粥样硬化性脑梗死患者60例,分为有糖尿病组30例和无糖尿病组30例,并另选30例健康体检者为正常对照组。测定静脉空腹血糖、HbA1c。结果:在ACI患者中糖尿病组的HbA1c水平明显高于非糖尿病组(P<0.05)。糖尿病组和无糖尿病组血糖水平明显升高,且与正常对照组比较差异有统计学意义(P<0.01),但二者之间血糖水平差异无统计学意义(P>0.05)。糖尿病组HbAlc,与无糖尿病组和正常对照组比较均差异有统计学意义(均P<0.01)。而无糖尿病组和正常对照组比较均差异无统计学意义(均P>0.05)。结论:高血糖、高HbAlc会增加ACI神经系统损伤,因此HbAlc测定是早期鉴别ACI应激性高血糖和糖尿病的可靠方法。可以对ACI并发糖尿病进行及时准确积极干预、治疗。HbAlc的测定在ACI的诊断中起重要的作用,是鉴别糖尿病性与非糖尿病性脑梗死的一个敏感指标。
Objective: To investigate the significance of glycosylated hemoglobin (HbA1c) in acute cerebral infarction (ACI). Methods: Sixty patients with acute atherosclerotic cerebral infarction were retrospectively analyzed. They were divided into 30 patients with diabetes mellitus and 30 patients without diabetes mellitus, and 30 healthy subjects were selected as normal control group. Venous fasting blood glucose, HbA1c. Results: HbA1c levels in diabetic patients were significantly higher than those in non-diabetic patients (P <0.05). The level of blood glucose in diabetic group and non-diabetic group was significantly higher than that in normal control group (P <0.01), but there was no significant difference in blood glucose level between the two groups (P> 0.05). HbAlc in diabetic group was significantly different from non-diabetic group and normal control group (all P <0.01). There was no significant difference between the non-diabetic group and the normal control group (all P> 0.05). CONCLUSIONS: Hyperglycemia and high HbA1c increase the nervous system injury of ACI. Therefore, HbA1c assay is a reliable method for early identification of ACI-induced hyperglycemia and diabetes mellitus. ACI complicated with diabetes can be timely and accurate positive intervention, treatment. The determination of HbAlc plays an important role in the diagnosis of ACI and is a sensitive indicator to identify diabetic and non-diabetic cerebral infarction.